Kyler Murray is ready to debut during the 2019 NFL Week 1.

2019 NFL Week 1 Odds, Overview & Predictions

Crazy weekend of trades and surprise roster moves around the NFL over the weekend, led by the Seattle Seahawks landing Texans defensive end Jadeveon Clowney, the former No. 1 overall pick. Yet Houston also got better by getting offensive lineman Laremy Tunsil and receiver Kenny Stills from Miami for draft picks. Here’s a look at every game on the Week 1 schedule, NFL odds and picks against the spread.

2019 NFL Week 1 Odds, Overview & Predictions

Green Bay at Chicago

Thursday night game. The Packers have largely dominated this series over the past decade but Chicago should have swept the Packers last year. They did win late in the season at Solider Field but blew a big third-quarter lead in Week 1 at Green Bay and lost. The Bears have covered their past seven games against NFC North foes and we think they do here. Pick: Bears.

Atlanta at Minnesota

Two teams who disappointed last year but are good enough to win a Super Bowl this year is they stay healthy and catch the right breaks. Atlanta made a late change in the preseason at kicker in re-signing Matt Bryant to a one-year, $3 million deal. Bryant was released in February and went unsigned through training camp. The Falcons didn’t like what they saw from Giorgio Tavecchio and Blair Walsh this preseason. Atlanta has failed to cover the past four in the series. Pick: Vikings.

Washington at Philadelphia

The Redskins aren’t likely going to be very good this year with Jay Gruden one of the favorites to be the first head coach fired. In a bit of a surprise, Gruden told reporters Monday that Derrius Guice will get more carries than Adrian Peterson this year. Guice missed all of last year with an injury. Pick: Redskins.

Buffalo at NY Jets (-3)

Pair of second-year quarterbacks face off in Josh Allen of Buffalo and Sam Darnold of the Jets. Both showed promising signs last year. Buffalo surprised many over the weekend in releasing veteran running back LeSean McCoy. That means rookie Devin Singletary likely will take over, although the team still has veterans Frank Gore and TJ Yeldon. Pick: Jets.

Baltimore at Miami

Miami is probably the worst team in the NFL, especially after trading two starters, offensive tackle Laremy Tunsil and receiver Kenny Stills, to Houston over the weekend. The team also shipped out linebacker Kiko Alonso in a salary dump. The Fins are tanking my friends. Pick: Ravens.

San Francisco at Tampa Bay

The 49ers have lost their past 12 games in the Eastern Time Zone. This will be the Bucs head coaching debut of Bruce Arians, the former Cardinals coach. Fifth-round rookie Matt Gay has won the Bucs’ kicking competition. Veteran Cairo Santos was released at final cuts Saturday. Pick: Bucs.

Kansas City at Jacksonville

Last year, the Chiefs beat the visiting Jaguars 30-14. Patrick Mahomes threw for 313 yards and ran for a score. The Chiefs defense picked off Blake Bortles four times and sacked him five. Kareem Hunt ran for 87 yards and a touchdown, and Travis Kelce hauled in five catches for 100 yards. Hunt’s gone now. Pick: Jaguars.

Tennessee at Cleveland

The Browns are a chic pick to win reach the first Super Bowl in franchise history this season; they are one of four active franchises to never make the game. The Titans have failed to cover the past four in this series. Pick: Browns.

LA Rams at Carolina

The Panthers will have quarterback Cam Newton. He injured his foot in Week 3 of the preseason but is good to go. For Newton, battling through injuries has become the norm. While he’s only missed five games in his career, he’s dealt with ankle issues, a fractured rib, a broken back suffered in a car accident, a torn rotator cuff and shoulder ailments in general. Pick: Panthers.

Cincinnati at Seattle

Top Bengals receiver AJ Green will miss this game and probably at least a few more. He’s still in a walking boot. The 31-year-old Green missed seven games last year and had career lows of 46 catches for 694 yards. He’s heading into the final year of his contract. Pick: Bengals.

Indianapolis at LA Chargers

This matchup looked like one of the best of Week 1 until the Colts saw star QB Andrew Luck retire. The Chargers, meanwhile, remain without Pro Bowl running back Melvin Gordon as he continues his holdout. Indy is 2-7 ATS in the past nine meetings. Pick: Chargers.

Detroit at Arizona

It’s the NFL debut of Cardinals quarterback Kyler Murray, last year’s Heisman Trophy winner at Oklahoma.

Kyler Murray is ready to debut during the 2019 NFL Week 1.

New Cardinals head coach Kliff Kingsbury believes Murray will be the perfect quarterback to lead his air raid offensive system. The Cards are just 1-4 ATS in their past five at home. Pick: Lions.

NY Giants at Dallas

Will the Cowboys have star running back Ezekiel Elliott? He continues to hold out for a new contract but the sides reportedly are close to a deal. If it doesn’t happen in the next 24 hours, it will be hard to envision Elliott being ready to play by Sunday. The Giants have failed to cover the past four in the series. Pick: Cowboys.

Pittsburgh at New England

Sunday night game. New England’s last loss in a game that counted was Week 15 of last season, 17-10 in Pittsburgh. Jaylen Samuels rushed for a career-high 142 yards for the Steelers. The Steelers had dropped five straight to New England and only beaten Tom Brady twice in his storied career. Pick: Patriots.

Houston at New Orleans

First Monday night game. Could be a Super Bowl preview, especially as Houston got better over the weekend with the trades for Miami’s Tunsil and Stills. Tunsil will protect Deshaun Watson’s backside, while Stills will immediately slot in as the No. 3 wideout behind DeAndre Hopkins and Will Fuller. Pick: Saints.

Denver at Oakland (pick’em)

Second Monday night game. It’s the Broncos debut of quarterback Joe Flacco and coach Vic Fangio. It’s the Oakland debut of former Steelers All-Pro receiver Antonio Brown. Pick: Broncos.

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